/* pipeline-rd.css — Pipeline / R&D page styles, matched to the Home.htm design system
 * (brand strip, logo header, slate nav bar, photo hero, square two-tone blocks, 4-column slate footer).
 * Image paths resolve when these files sit beside Home.htm.
 */
:root{
  --slate:#324158;--slate-2:#38475c;--slate-3:#515e71;--slate-4:#5b6779;--slate-5:#7a8392;
  --navy:#1f2f50;--teal:#2a6e7d;--gold:#c49b3c;--gold-dk:#9c7430;
  --tan:#b89a6a;--tan-lt:#c8b089;--grey:#787676;--grey-lt:#8b8a8a;
  --ink:#33404e;--muted:#6b7686;--line:#dfe4ec;--soft:#f7f9fc;--strip:#eeeeee;--white:#fff;
  --wrap:1180px;
  --sans:Arial,Helvetica,sans-serif;--display:Raleway,Arial,Helvetica,sans-serif;
}
.p-rd,.p-rd *{box-sizing:border-box}
html{scroll-behavior:smooth}
.p-rd [id]{scroll-margin-top:72px}
.p-rd{color:var(--ink);font:400 16px/1.55 var(--sans);font-variant-numeric:lining-nums;background:#fff}
.p-rd img{max-width:100%}
.p-rd :where(a){color:var(--slate)}
.p-rd :where(a:hover){text-decoration:underline}
.sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}
.skip-link{position:absolute;left:12px;top:-60px;z-index:50;background:var(--slate);color:#fff;padding:10px 14px;font-weight:700}
.skip-link:focus{top:12px}
.p-rd :focus-visible{outline:3px solid var(--gold);outline-offset:2px}

/* ── Brand strip (sister-brand logos, as on Home) ────────────────────── */
.brand-strip{background:var(--strip);border-bottom:1px solid #d6d6d6;box-shadow:0 6px 10px -6px rgba(0,0,0,.35)}
.brand-strip__inner{display:flex;justify-content:center;max-width:var(--wrap);margin:0 auto;overflow-x:auto;scrollbar-width:none}
.brand-strip__inner::-webkit-scrollbar{display:none}
.brand-strip a{flex:0 0 auto;display:flex;align-items:center;justify-content:center;height:56px;padding:0 14px;border-right:1px solid #d0d0d0}
.brand-strip a:first-child{border-left:1px solid #d0d0d0;background:#fff}
.brand-strip img{display:block;height:22px;width:auto;opacity:.75;transition:opacity .2s}
.brand-strip a:first-child img{height:34px;opacity:1}
.brand-strip a:hover img{opacity:1}

/* ── Logo header ─────────────────────────────────────────────────────── */
.site-header{background:#fff}
.site-header__inner{display:flex;align-items:center;justify-content:space-between;gap:24px;max-width:980px;margin:0 auto;padding:22px 24px}
.brand{display:flex;align-items:center;color:var(--navy);font:700 22px var(--display);text-decoration:none}
.brand:hover{text-decoration:none}
.brand img{display:block;height:64px;width:auto}
.header-mail{display:inline-flex;align-items:center;gap:8px;color:var(--ink);font-size:13px;letter-spacing:.02em;text-decoration:none}
.header-mail img{width:20px;height:auto}

/* ── Slate nav bar ───────────────────────────────────────────────────── */
.main-nav{position:sticky;top:0;z-index:20;background:var(--slate);box-shadow:0 2px 10px rgba(0,0,0,.18)}
.main-nav__inner{display:flex;justify-content:center;max-width:var(--wrap);margin:0 auto;overflow-x:auto;scrollbar-width:none}
.main-nav__inner::-webkit-scrollbar{display:none}
.main-nav a{flex:0 0 auto;position:relative;padding:20px 22px;color:#fff;font:400 16px/1 var(--sans);text-transform:uppercase;letter-spacing:.02em;text-decoration:none;white-space:nowrap}
.main-nav a::after{content:"";position:absolute;left:22px;right:22px;bottom:10px;height:2px;background:var(--gold);transform:scaleX(0);transition:transform .2s}
.main-nav a:hover::after,.main-nav a.active::after{transform:scaleX(1)}
.main-nav a.active{font-weight:700}

/* ── Hero (Home hero image + slate wash) ─────────────────────────────── */
.hero{position:relative;display:grid;place-items:center;min-height:390px;padding:64px 24px;text-align:center;color:#fff;
  background:linear-gradient(rgba(31,47,80,.58),rgba(31,47,80,.58)),url("Home_data/bd9b2b_83920f932d9d4ee39f0f38fc139f0ebf_mv2.png") center/cover no-repeat,var(--slate)}
.hero__content{max-width:860px}
.hero .eyebrow{color:#f1d48a}
.hero h1{margin:0;font:700 clamp(40px,6vw,64px)/1.1 var(--display);text-shadow:0 2px 14px rgba(0,0,0,.35)}
.hero__rule{display:block;width:44px;height:3px;margin:18px auto;background:#fff}
.lead{margin:0 auto;max-width:760px;font-size:clamp(18px,2vw,23px);line-height:1.4;text-shadow:0 1px 8px rgba(0,0,0,.4)}
.eyebrow{margin:0 0 10px;color:var(--gold-dk);font:700 13px/1.2 var(--sans);text-transform:uppercase;letter-spacing:.16em}

/* ── Square two-tone blocks (FAST FACTS / ABOUT AOXING pattern) ──────── */
.block-band{display:grid;grid-template-columns:1fr 1fr}
.block{display:flex;flex-direction:column;color:#fff}
.block__title{margin:0;padding:22px clamp(24px,9vw,134px);font:700 28px/1.2 var(--display);text-transform:uppercase;letter-spacing:.01em;color:#fff}
.block__body{flex:1;padding:22px clamp(24px,9vw,134px) 48px}
.block--grey .block__title{background:var(--slate-2)}
.block--grey .block__body{background:var(--slate-5)}
.block--slate .block__title{background:var(--slate)}
.block--slate .block__body{background:var(--slate-3)}
.block--tan .block__title{background:var(--tan)}
.block--tan .block__body{background:var(--tan-lt);color:#2b2a26}
.block--stone .block__title{background:var(--grey)}
.block--stone .block__body{background:var(--grey-lt)}
.block__lede{margin:0 0 16px;font:700 22px/1.3 var(--display)}
.block__body p{margin:0 0 16px;letter-spacing:.01em}

.facts{margin:0;padding:0;list-style:none}
.facts li{margin:0 0 18px}
.facts dt,.fact-label{display:block;font-size:16px;text-transform:uppercase;letter-spacing:.02em}
.fact-value{display:block;font:700 34px/1.15 var(--sans)}
.fact-value small{font-size:13px;font-weight:700}

.btn{display:inline-block;padding:13px 38px;border:1px solid #fff;border-radius:2px;background:#fff;color:#2b2a26;font:700 14px/1 var(--display);text-decoration:none;cursor:pointer;transition:background .2s,color .2s}
.btn:hover{background:transparent;color:#fff;text-decoration:none}

.filter-label{display:block;margin:6px 0 8px;font-weight:700;text-transform:uppercase;letter-spacing:.06em;font-size:13px}
.entity-select{width:100%;max-width:440px;padding:13px 14px;border:1px solid rgba(255,255,255,.6);border-radius:2px;background:#fff;color:var(--ink);font:400 16px var(--sans)}
.filter-status{margin:12px 0 0!important;font-size:14px;color:#e6ebf2}

/* ── Section wrapper ─────────────────────────────────────────────────── */
.pipeline-section{max-width:var(--wrap);margin:0 auto;padding:64px 24px}
.section-heading{display:flex;flex-wrap:wrap;align-items:flex-end;justify-content:space-between;gap:16px 32px;margin-bottom:24px}
.section-heading h2{margin:0;color:var(--slate);font:700 clamp(26px,3vw,36px)/1.2 var(--display);text-transform:uppercase}
.section-heading h2::after{content:"";display:block;width:56px;height:3px;margin-top:14px;background:var(--gold)}
.therapeutic-areas>.pipeline-section{padding-bottom:8px}
.section-heading p:not(.eyebrow){max-width:760px;margin:12px 0 0;color:var(--muted);font-size:17px}

.legend{display:flex;flex-wrap:wrap;gap:18px;margin:0;padding:0;list-style:none;font-size:13px;color:var(--muted);text-transform:uppercase;letter-spacing:.05em}
.legend li{display:flex;align-items:center;gap:8px}
.legend i{display:block;width:28px;height:10px;border-radius:999px;background:#e5e9f0}
.legend .is-complete{background:linear-gradient(90deg,var(--slate),var(--slate-5))}
.legend .is-active{background:linear-gradient(90deg,var(--gold),#ebc967)}

/* ── Pipeline table ──────────────────────────────────────────────────── */
.pipeline-scroll{width:100%;overflow-x:auto;-webkit-overflow-scrolling:touch}
.pipeline-table{min-width:960px;border:1px solid var(--line);background:#fff;box-shadow:0 14px 34px rgba(31,47,80,.10)}
.pipeline-row{display:grid;grid-template-columns:56px 1.35fr 1.1fr repeat(5,.72fr);align-items:stretch;border-bottom:1px solid var(--line);transition:background .2s}
.pipeline-row:last-child{border-bottom:0}
.pipeline-row>div,.pipeline-row>button{padding:16px 12px;display:flex;align-items:center;border-right:1px solid var(--line)}
.pipeline-row>:nth-child(8){border-right:0}
.pipeline-head{background:var(--slate);color:#fff;font:700 12px/1.2 var(--sans);text-transform:uppercase;letter-spacing:.08em}
.pipeline-head>div{border-right-color:rgba(255,255,255,.14)}
.program-row:hover{background:#fafbfd}
.program-row.is-open{background:var(--soft);box-shadow:inset 4px 0 0 var(--gold)}

/* Toggle — left side, spans its own column */
.toggle{font:300 28px/1 var(--sans);color:var(--slate);background:transparent;border:0;border-right:1px solid var(--line);cursor:pointer;justify-content:center!important;padding:8px!important}
.toggle:hover{background:#eef2f7}
.toggle:focus-visible{outline:3px solid var(--gold);outline-offset:-3px}
.is-open .toggle{color:var(--gold-dk)}

.program{flex-direction:column!important;align-items:flex-start!important;justify-content:center;gap:4px}
.program strong{color:var(--slate);font:700 17px/1.25 var(--display)}
.program span{color:var(--muted);font-size:13px}
.indication a{font-weight:700;text-decoration:underline;text-underline-offset:3px;text-decoration-color:rgba(50,65,88,.35)}

/* Phase bars */
.stage{position:relative;justify-content:center;font-size:0}
.stage::before{content:"";display:block;width:100%;height:12px;border-radius:999px;background:#e5e9f0}
.stage.complete::before{background:linear-gradient(90deg,var(--slate),var(--slate-5))}
.stage.active::before{background:linear-gradient(90deg,var(--gold),#ebc967);box-shadow:0 0 0 4px rgba(196,155,60,.18)}

/* ── Accordion detail panel ──────────────────────────────────────────────
 * Selector carries the row prefix so it outranks `.pipeline-row>div{display:flex}`,
 * which otherwise lays the heading/paragraph/list out side by side. */
.pipeline-row>.program-details{grid-column:1/-1;display:block;border-right:0;border-top:0 solid var(--line);background:#fff;padding:0 78px;max-height:0;overflow:hidden;opacity:0;visibility:hidden;transition:max-height .45s ease,opacity .3s ease,padding .3s ease,border-top-width .3s ease,visibility 0s linear .45s}
.pipeline-row.is-open>.program-details{border-top-width:1px;padding:24px 78px 28px;max-height:640px;opacity:1;visibility:visible;transition:max-height .45s ease,opacity .3s ease,padding .3s ease,border-top-width .3s ease,visibility 0s}
.program-details h3{margin:0 0 10px;color:var(--slate);font:700 20px/1.3 var(--display)}
.program-details p{max-width:850px;line-height:1.6;margin:0 0 12px}
.program-details ul{margin:0 0 14px;padding:0;list-style:none;line-height:1.6}
.program-details li{position:relative;padding:0 0 6px 22px}
.program-details li::before{content:"";position:absolute;left:0;top:7px;width:9px;height:9px;border-radius:2px;background:var(--slate)}
.nct{display:inline-block;margin:4px 0 0!important;padding:8px 14px;border-left:3px solid var(--gold);background:#faf7ef;font-size:14px;color:var(--muted)}
.nct strong{color:var(--slate);text-transform:uppercase;letter-spacing:.05em;font-size:12px;margin-right:4px}
.nct a{font-weight:700}

/* ── Per-entity overview (tan block, cards filter the chart) ─────────── */
.overview-grid{display:grid;grid-template-columns:repeat(5,1fr);gap:14px}
.overview-card{display:flex;flex-direction:column;align-items:flex-start;text-align:left;padding:22px;border:1px solid rgba(255,255,255,.55);border-radius:0;background:rgba(255,255,255,.28);color:#2b2a26;font:inherit;cursor:pointer;transition:background .2s,transform .2s,box-shadow .2s}
.overview-card:hover{background:rgba(255,255,255,.5);transform:translateY(-2px)}
.overview-card[aria-pressed="true"]{background:#fff;box-shadow:inset 0 4px 0 var(--slate)}
.overview-card span{display:grid;place-items:center;width:36px;height:36px;margin-bottom:14px;background:var(--slate);color:#fff;font-weight:700}
.overview-card h3{margin:0 0 8px;color:var(--slate);font:700 17px/1.3 var(--display)}
.overview-card p{margin:0;font-size:14px;line-height:1.5}
.overview-card em{margin-top:auto;padding-top:14px;font:700 12px/1 var(--sans);font-style:normal;text-transform:uppercase;letter-spacing:.08em;color:var(--slate)}

/* ── Therapeutic area tiles (hexagon motif, as on the Philanthropy banner) ── */
.area-cards{display:grid;grid-template-columns:repeat(2,1fr);gap:0}
.area-card{position:relative;overflow:hidden;display:flex;flex-direction:column;justify-content:flex-end;min-height:260px;padding:32px 40px;color:#fff;text-decoration:none;background:linear-gradient(115deg,#1f2f50 0%,#23506a 55%,#2a6e7d 100%)}
.area-card+.area-card{background:linear-gradient(115deg,#324158 0%,#515e71 55%,#7a8392 100%)}
.area-card::before{content:"";position:absolute;inset:0;opacity:.14;transition:opacity .3s;
  background:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='112' height='97' viewBox='0 0 112 97'%3E%3Cg fill='none' stroke='%23ffffff' stroke-width='1.6'%3E%3Cpath d='M28 1 L56 17 L56 49 L28 65 L0 49 L0 17 Z'/%3E%3Cpath d='M84 33 L112 49 L112 81 L84 97 L56 81 L56 49 Z'/%3E%3C/g%3E%3C/svg%3E") repeat}
.area-card:hover{text-decoration:none}
.area-card:hover::before{opacity:.26}
.area-card>*{position:relative}
.area-card span{color:#f2d890;font-weight:700;letter-spacing:.14em}
.area-card strong{margin:10px 0 6px;color:#fff;font:700 30px/1.15 var(--display);text-transform:uppercase}
.area-card strong::after{content:"";display:block;width:44px;height:3px;margin-top:12px;background:var(--gold)}
.area-card em{font-style:normal;color:#e6edf5}
.area-card b{margin-top:16px;font:700 13px/1 var(--sans);text-transform:uppercase;letter-spacing:.1em}

/* ── Footer (4 graded slate columns, as on Home) ─────────────────────── */
.site-footer{display:grid;grid-template-columns:repeat(4,1fr);font-family:var(--sans)}
.footer-col{display:flex;flex-direction:column}
.footer-col:nth-child(1){background:var(--slate)}
.footer-col:nth-child(2){background:var(--slate-3)}
.footer-col:nth-child(3){background:var(--slate-4)}
.footer-col:nth-child(4){background:var(--slate-5)}
.footer-col h2{margin:0;min-height:116px;display:flex;align-items:center;padding:24px 24px 24px 22%;color:#fff;font:700 16px/1.3 lulo-clean-w01-one-bold,"Arial Black",Arial,sans-serif;letter-spacing:.16em;text-transform:uppercase}
.footer-col div{flex:1;padding:26px 24px 44px 22%;background:rgba(255,255,255,.06)}
.footer-col a,.footer-col p{display:block;margin:0 0 12px;color:#fff;font-size:15px;line-height:1.4;text-decoration:none}
.footer-col a:hover{text-decoration:underline}
.footer-bar{display:flex;justify-content:space-between;gap:12px 24px;flex-wrap:wrap;padding:18px clamp(20px,5vw,72px);background:var(--navy);color:#cfd8e3;font-size:13px}
.footer-bar p{margin:0}
.footer-bar a{color:#f2d890;font-weight:700}

.hidden-row{display:none!important}

/* ── Therapeutic-area sample pages ───────────────────────────────────── */
.ta-page .hero{min-height:300px}
.breadcrumbs{max-width:980px;margin:0 auto;padding:18px 24px;font-size:14px;color:var(--muted)}
.breadcrumbs a{font-weight:700}
.content-card{max-width:980px;margin:0 auto 64px;padding:40px 48px;border:1px solid var(--line);border-top:4px solid var(--slate);background:#fff;box-shadow:0 14px 34px rgba(31,47,80,.08)}
.content-card h2{margin:32px 0 12px;color:var(--slate);font:700 24px/1.25 var(--display);text-transform:uppercase}
.content-card h2::after{content:"";display:block;width:44px;height:3px;margin-top:10px;background:var(--gold)}
.content-card p{margin:0 0 16px;font-size:17px;line-height:1.65}
.resource-list{display:flex;flex-wrap:wrap;gap:10px;margin:24px 0}
.resource-list a{display:inline-block;padding:10px 16px;border:1px solid var(--slate);border-radius:4px;color:var(--slate);font-size:14px;font-weight:700;text-decoration:none}
.resource-list a:hover{background:var(--slate);color:#fff}
.back-link{display:inline-block;font-weight:700;text-transform:uppercase;letter-spacing:.06em;font-size:13px}
.back-link::before{content:"\2190  "}

/* ══ Breakpoints ═════════════════════════════════════════════════════ */

/* Large laptop / small desktop */
@media (max-width:1200px){
  .pipeline-row{grid-template-columns:50px 1.25fr .95fr repeat(5,.66fr)}
  .pipeline-row>.program-details{padding:0 66px}
  .pipeline-row.is-open>.program-details{padding:20px 66px 24px}
  .overview-grid{grid-template-columns:repeat(3,1fr)}
}

/* Tablet landscape */
@media (max-width:1024px){
  .main-nav__inner{justify-content:flex-start}
  .main-nav a{padding:18px 16px;font-size:14px}
  .main-nav a::after{left:16px;right:16px}
  .block__title,.block__body{padding-left:40px;padding-right:40px}
  .footer-col h2,.footer-col div{padding-left:28px}
  .pipeline-row>.program-details{padding:0 46px}
  .pipeline-row.is-open>.program-details{padding:16px 46px 20px}
}

/* Tablet portrait / large phone */
@media (max-width:768px){
  .site-header__inner{padding:16px}
  .brand img{height:48px}
  .hero{min-height:300px;padding:48px 16px}
  .block-band{grid-template-columns:1fr}
  .block__title{font-size:24px;padding:18px 24px}
  .block__body{padding:20px 24px 36px}
  .pipeline-section{padding:44px 16px}
  .overview-grid{grid-template-columns:repeat(2,1fr)}
  .area-cards{grid-template-columns:1fr}
  .site-footer{grid-template-columns:repeat(2,1fr)}
  .footer-col h2{min-height:80px}
  .content-card{margin:0 16px 48px;padding:28px 24px}
  .breadcrumbs{padding:16px}
}

/* Phone */
@media (max-width:600px){
  .brand-strip a{height:46px;padding:0 10px}
  .brand-strip img{height:18px}
  .brand-strip a:first-child img{height:28px}
  .header-mail span{display:none}
  .hero{min-height:250px}
  .fact-value{font-size:28px}
  .overview-grid{grid-template-columns:1fr}
  .area-card{min-height:210px;padding:28px 24px}
  .area-card strong{font-size:24px}
  .site-footer{grid-template-columns:1fr}
  .footer-col h2{min-height:0;padding:20px 24px}
  .footer-col div{padding:16px 24px 24px}
  .pipeline-row>.program-details{padding:0 24px}
  .pipeline-row.is-open>.program-details{padding:14px 24px 18px}
}

/* Very small phones */
@media (max-width:400px){
  .brand img{height:40px}
  .main-nav a{padding:16px 12px;font-size:13px}
  .main-nav a::after{left:12px;right:12px}
}

@media (prefers-reduced-motion:reduce){
  html{scroll-behavior:auto}
  .p-rd *,.p-rd *::before,.p-rd *::after{transition:none!important}
}